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Natural Killer Cell Mechanosensing in Solid Tumors

https://doi.org/10.3390/bioengineering11040328

Lightsey, Suzanne; Sharma, Blanka (April 2024, Bioengineering)

Natural killer (NK) cells, which are an exciting alternative cell source for cancer immunotherapies, must sense and respond to their physical environment to traffic to and eliminate cancer cells. Herein, we review the mechanisms by which NK cells receive mechanical signals and explore recent key findings regarding the impact of the physical characteristics of solid tumors on NK cell functions. Data suggest that different mechanical stresses present in solid tumors facilitate NK cell functions, especially infiltration and degranulation. Moreover, we review recent engineering advances that can be used to systemically study the role of mechanical forces on NK cell activity. Understanding the mechanisms by which NK cells interpret their environment presents potential targets to enhance NK cell immunotherapies for the treatment of solid tumors.
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Manufacturing of natural killer cells for treating solid malignancies

https://doi.org/10.1016/j.regen.2020.100031

Temples, Madison N.; Sharma, Blanka (December 2020, Journal of Immunology and Regenerative Medicine)
null (Ed.)
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Engineered Three-Dimensional Tumor Models to Study Natural Killer Cell Suppression

https://doi.org/10.1021/acsbiomaterials.0c00259

Temples, Madison N.; Adjei, Isaac M.; Nimocks, Phoebe M.; Djeu, Julie; Sharma, Blanka (July 2020, ACS Biomaterials Science & Engineering)
null (Ed.)
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